The Tour De OROC fundraiser ride is cycling 800 kilometres through the Western Plain's wild weather this week for the annual Macquarie Home Stay fundraiser.

Hosted by the Rotary Club of Dubbo South, this year 37 riders will pedal through the Orana Region, starting in Dubbo on October 6 and finishing in Coonamble on October 11.

After kicking off the tour on Monday, the group has zoomed from Dubbo to Warren to the Macquarie Marshes, and then Nyngan and to Cobar.

Originally from Warren, the chair of the Rotary Club of Dubbo South Tour de OROC fundraising committee, Ben O'Brien will be joining the group for his third ride for the charity.

On the tour's way into Warren on Monday they were accompanied by a special guest.

Warren Mayor Greg Whiteley, who said he had not sat on a bike in 35 years, rode 5 kilometres into town with the flock for the "unbelievable charity."

"The community spirit behind the Homestead, especially for the communities further away than us, is really good," he said.

Mayor Greg Whiteley mounting a bike for the first time this century [IMAGE: SUPPLIED]

But Mr Whiteley said after their first day on the road there were a few muscles felt, and riders were "a little bit sore in the saddle".

"I think yesterday from Nyngan to Cobar might've been a bit horrific into that wind," Mr Whiteley said.

Although Mr O'Brien said the ride from Warren to Cobar went well, he said the Nyngan to Cobar straight was "atrocious."

"We've experienced almost every weather condition you can have."

But he remains optimistic about the charity event.

Mr O'Brien says they are almost halfway to their $250,000 goal, with around $100,000 raised.

The charity ride raises funds for Macquarie Home Stay, which provides cheap accommodation for patients who have needed to travel to Dubbo for healthcare and treatment services.

This year funds will go towards building family orientated rooms, including an accommodation unit, for the patients in the home stay.

Today they were tackling the Cobar to Bourke straight, but the breeze will be pushing against them again, with south-westerly winds from 15-25kms/phr.

The group has covered around 130 kms daily, but today this has pushed to 160kms - the biggest day of the tour.

Over one million dollars has been raised in funds since the Tour De OROC cycle event began in 2013.

The Rotary club is also drawing a raffle with funds going towards the Macquarie Home Stay.

Tickets cost $10 each, and the top prize is a high class, 3 night Melbourne escape for two.

Tickets are available online.